The CSF-1 receptor (CSF-1R) is activated with the homodimeric growth factors colony-stimulating factor-1 (CSF-1) and interleukin-34 (IL-34). of CSF-1 IL-34 and the CSF-1R and the mechanism of ligand binding to and activation from the receptor. We further explain the pathways regulating macrophage survival proliferation differentiation and chemotaxis downstream from the CSF-1R. The glycoprotein colony-stimulating factor-1… Continue reading The CSF-1 receptor (CSF-1R) is activated with the homodimeric growth factors