The inflammatory microenvironment promotes epidermis tumorigenesis. cytokine-induced IKKα activation promoted the formation of NPM oligomers and reduced centrosome numbers in mouse and human cells whereas kinase-dead IKKα blocked this connection. Therefore our findings suggest a previously unknown mechanism where an IKKα-NPM axis might use the inflammatory sign to suppress centrosome amplification promote genomic integrity and… Continue reading The inflammatory microenvironment promotes epidermis tumorigenesis. cytokine-induced IKKα activation promoted the