BACKGROUND & AIMS Hyperhomocysteinemia is often associated with liver and metabolic diseases. and the liver responses to ethanol and homocysteine. SHP inhibits the transcriptional activation of and by FOXA1. gene expression.8 Numerous studies suggest that SHP has pleiotropic roles in the pathology of chronic liver diseases. In lipid metabolism SHP facilitates hepatic lipid accumulation since… Continue reading BACKGROUND & AIMS Hyperhomocysteinemia is often associated with liver and metabolic