2011;6:e20399. for Cucurbitacin S disease recurrence years after radical treatment causing a massive clinical problem in prostate cancer. Thus, developing means for destroying disseminated prostate cancer stem-like cells is an important goal of modern cancer research. The results presented in this study suggest that multiple subpopulation of putative prostate cancer stem-like cells characterized by distinct molecular signatures can be attacked using a single target commonly expressed on these cells, the TF-Ag. tumor cell adhesion in the pulmonary microvasculature is usually exclusively mediated by tumor cell–endothelial cell conversation. BMC Cancer. 2010;10:177. https://doi.org/10.1186/1471-2407-10-177 [PMC free article] [PubMed] [Google Scholar] 10. Glinsky VV, Glinsky GV, Glinskii OV, Huxley Cucurbitacin S VH, Turk JR, Mossine VV, Deutscher SL, Pienta KJ, Quinn TP. Intravascular metastatic cancer cell homotypic aggregation at the sites of primary attachment to the endothelium. Cancer Res. 2003;63:3805C3811. [PubMed] [Google Scholar] 11. Glinsky VV. Intravascular cell-to-cell adhesive interactions and bone metastasis. Cancer Metastasis Rev. 2006;25:531C540. [PubMed] [Google Scholar] 12. Murugaesu N, Iravani M, van Weverwijk A, Ivetic A, Johnson DA, Antonopoulos A, Fearns A, Jamal-Hanjani M, Sims D, Fenwick K, Mitsopoulos C, Gao Q, Orr N, et al. An in vivo functional screen identifies ST6GalNAc2 sialyltransferase as a breast cancer metastasis suppressor. Cancer Discov. 2014;4:304C317. [PubMed] [Google Scholar] 13. Reticker-Flynn NE, Bhatia SN. Aberrant glycosylation promotes lung cancer metastasis through adhesion to galectins in the metastatic niche. Cancer Discov. 2015;5:168C181. [PMC free article] [PubMed] [Google Scholar] 14. Storr SJ, Royle L, Chapman CJ, Hamid UM, Robertson JF, Murray A, Dwek RA, Rudd PM. The O-linked glycosylation of secretory/shed MUC1 from an advanced breast cancer patient’s serum. Glycobiology. 2008;18:456C462. [PubMed] [Google Scholar] 15. Singh R, Campbell BJ, Yu LG, Fernig DG, Milton JD, Goodlad RA, FitzGerald AJ, Rhodes JM. Cell surface-expressed Thomsen-Friedenreich antigen in colon cancer is usually predominantly carried on high molecular weight splice variants of CD44. Glycobiology. 2001;11:587C592. [PubMed] [Google Scholar] 16. Lin WM, Karsten U, Goletz S, Cheng RC, Cao Y. Expression of CD176 (Thomsen-Friedenreich antigen) on lung, breast and liver cancer-initiating cells. Int J Exp Pathol. 2011;92:97C105. [PMC free article] [PubMed] [Google Scholar] 17. Cao Y, Merling A, Karsten U, Goletz S, Punzel M, Kraft R, Butschak G, Schwartz-Albiez R. Expression of CD175 (Tn), CD175s (sialosyl-Tn) and CD176 (Thomsen-Friedenreich antigen) on malignant human hematopoietic cells. Int J Cancer. 2008;123:89C99. [PubMed] [Google Scholar] 18. CD8B Tu SM, Lin SH. Prostate cancer stem cells. Clin Genitourin Cancer. 2012;10:69C76. [PMC free article] [PubMed] [Google Scholar] 19. Engelmann K, Shen H, Finn OJ. MCF7 side population cells with characteristics of cancer stem/progenitor cells express the tumor antigen MUC1. Cancer Res. 2008;68:2419C2426. [PubMed] [Google Scholar] 20. Curry JM, Thompson KJ, Rao S, Ahrens WA, McKillop IH, Sindram D. Pancreatic cancer stem cells (CSCs) express MUC1 and MUC1-expressing pancreatic cancers encompass higher levels of CSCs. Cancer Res; In: Proceedings of the 102nd Annual Getting together with of the American Association for Cancer Research; 2011 Apr 2C6;; Orlando, FL. Philadelphia (PA). 2011. Abstract nr 2454. [Google Scholar] 21. Stroopinsky D, Rosenblatt J, Ito K, Cucurbitacin S Mills H, Yin L, Rajabi H, Vasir B, Kufe T, Luptakova K, Arnason J, Nardella C, Levine JD, Joyce RM, et al. MUC1 Is usually a Potential Target for the Treatment of Acute Myeloid Leukemia Stem Cells. Cancer Res. 2013;73:5569C5579. [PMC free article] [PubMed] [Google Scholar] 22. Mulholland DJ, Xin L, Morim A, Lawson D, Witte O, Wu H. Lin-Sca-1+CD49fhigh stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer model. Cancer Res. 2009;69:8555C62. [PMC free article] [PubMed] [Google Scholar] 23. Yamamoto H, Masters JR, Dasgupta P, Chandra A, Popert R, Freeman A, Ahmed A. CD49f is an efficient marker of monolayer- and spheroid colony-forming cells of the benign and malignant human prostate. PLoS One. 2012;7:e46979. [PMC free article] [PubMed] [Google Scholar] 24. Notta F, Doulatov S, Laurenti E, Poeppl A, Jurisica.