Our understanding of the biological principles of mycobacterial tolerance to antibiotics is crucial for developing shorter anti-tuberculosis regimens. development of these structures is usually genetically programmed and defective biofilms of isogenic mutants harbor fewer persisters. Thus genetic analysis of mycobacterial biofilms in vitro could potentially be a powerful tool to unravel the biology of drug… Continue reading Our understanding of the biological principles of mycobacterial tolerance to antibiotics
Category: mGlu Group III Receptors
Nitric oxide activation of soluble guanylyl cyclase (sGC) blunts the cardiac
Nitric oxide activation of soluble guanylyl cyclase (sGC) blunts the cardiac stress response including cardiomyocyte hypertrophy. from caveolae-enriched lipid raft microdomains at different levels; sGCβ1 at 4wkMR accompanied by sGCα1 at 12moMR. Appearance of both sGC subunits fell in 12moMR moreover. Using the heme-dependent NO donor DEA/NO and NO-/heme-independent sGC activator BAY 60-2770 we motivated… Continue reading Nitric oxide activation of soluble guanylyl cyclase (sGC) blunts the cardiac
Targeted busulfan/cyclophosphamide (TBU/CY) for allogeneic hematopoietic cell transplantation (HCT) carries a
Targeted busulfan/cyclophosphamide (TBU/CY) for allogeneic hematopoietic cell transplantation (HCT) carries a high risk of sinusoidal obstruction syndrome (SOS) in patients transplanted for myelofibrosis. followed by daily IV BU for four days targeted to a concentration at steady state (Css) of 800-900 ng/mL. CY/TBU-conditioned patients had higher exposure to CY (p