The C3 toxins from (C3bot) and (C3lim) as well as C3-derived fusion proteins are selectively taken up into the cytosol of monocytes/macrophages where the C3-catalyzed ADP-ribosylation of Rho results in inhibition of Rho-signalling and characteristic morphological changes. results indicate that Rho-activity is usually crucial during the early phase of osteoclast-differentiation. Other bone 183320-51-6 IC50 cell… Continue reading The C3 toxins from (C3bot) and (C3lim) as well as C3-derived