Grouping variants predicated on gene mapping can augment the power of rare variant association checks. splice-site alterations, and stop gains were assigned to the protein damaging category. Effect of noncoding variants is more difficult to forecast. We decided to rely distinctively on conservation: we combined (a) the mammalian phastCons Conserved Element and (b) the PhyloP… Continue reading Grouping variants predicated on gene mapping can augment the power of