The exclusive localization of the histone H3 variant CENP-A to centromeres is essential for accurate chromosome segregation. CENP-ACse4. The down-regulated genes are enriched for CENP-ACse4 mislocalization to promoters, while the up-regulated genes correlate with those that are also transcriptionally up-regulated in an strain. Together, these data show that regulating centromeric nucleosome localization is not only… Continue reading The exclusive localization of the histone H3 variant CENP-A to centromeres