Myelodysplastic syndromes (MDSs) are clonal hematologic disorders that frequently represent an intermediate disease stage before progression to acute myeloid leukemia (AML). is the dominant mechanism for TSG silencing and clonal variation in MDS evolution to AML. Introduction Loss of heterozygosity (LOH) is an important event in neoplasia. For example, in the myeloid malignancies myelodysplastic syndrome… Continue reading Myelodysplastic syndromes (MDSs) are clonal hematologic disorders that frequently represent an