Supplementary Materials Supplementary Data supp_39_10_4396__index. that we analyzed in disease-causing mutations at E+1 potentially helps identify yet unrecognized splicing mutations at E+1. INTRODUCTION In higher eukaryotes, generation of functional mRNA is dependent on the removal of introns from pre-mRNA by splicing (1). The splicing process occurs in the spliceosome, the major components of which include… Continue reading Supplementary Materials Supplementary Data supp_39_10_4396__index. that we analyzed in disease-causing mutations