T cells could be engineered to express the genes of chimeric antigen receptors (CARs) that recognize tumor-associated antigens. activation with an anti-CD3 monoclonal antibody (OKT3) prior to transduction followed by a second OKT3 stimulation seven days after transduction. This protocol was successfully adapted for use in CLL patients with high peripheral blood leukemia cell AMG… Continue reading T cells could be engineered to express the genes of chimeric