Huntington’s disease (HD) is a late-onset and progressive neurodegenerative disorder that is caused by aggregation of mutant huntingtin protein which contains expanded-polyglutamine. which is an important factor for vesicle trafficking in the neuronal cells [12]. Htt also binds to repressor element 1 transcription factor/neuron restrictive silencer factor (REST/NRSF) which is involved in transcriptional repression [13].… Continue reading Huntington’s disease (HD) is a late-onset and progressive neurodegenerative disorder that