Background Tissue injury triggers inflammatory reactions that promote cells fibrosis; however the mechanisms that couple cells injury swelling and fibroblast activation are not known. Methods and Results The freeze-thaw technique was used to induce myocardial necrosis in freshly excised mouse hearts. Supernatants from NMCs contained multiple DAMPs including high mobility group package-1 (HMGB1) galectin-3 S100β… Continue reading Background Tissue injury triggers inflammatory reactions that promote cells fibrosis; however