Valosin-containing protein (VCP or p97) is necessary for the proteasomal degradation of polyubiquitinated proteins. evaluation showed that either D2 or D1 area of VCP is enough to handle this unfolding activity. The structure from the substrates affects its unfolding by VCP also. VCP struggles to unfold Ub5-DHFR in a good framework when it binds with… Continue reading Valosin-containing protein (VCP or p97) is necessary for the proteasomal degradation