The ATPase subunits from the SWI/SNF chromatin remodeling enzymes Brahma (BRM) and Brahma related gene 1 (BRG1) can induce cell cycle arrest in BRM and BRG1 deficient tumor cell lines and mice heterozygous for Brg1 are predisposed to breast tumors implicating lack of BRG1 being a mechanism for unregulated cell proliferation. improved in three-dimensional rBM… Continue reading The ATPase subunits from the SWI/SNF chromatin remodeling enzymes Brahma (BRM)