Epistatic interactions between killer cell immunoglobulin-like receptors (KIRs) and their cognate HLA class I ligands have important implications for reproductive success antiviral immunity susceptibility to autoimmune conditions and cancer as well as for graft-versus-leukemia reactions in settings of allogeneic stem cell transplantation. function was impartial of expression of self-HLA class I ligands. Finally despite similarities… Continue reading Epistatic interactions between killer cell immunoglobulin-like receptors (KIRs) and their cognate