Supplementary MaterialsSupplementary Details Supplementary Body 1 ncomms10049-s1. initial pathogenic mutation discovered in individual mutation p.L811P, which confers gain-of-function properties to NaV1.9 and causes congenital insensitivity to discomfort15,16. Further research have connected gain-of-function mutations in NaV1.9 to familial episodic suffering and painful neuropathy17,18,19. At the moment it isn’t clear the way the gain-of-function of NaV1.9 channels… Continue reading Supplementary MaterialsSupplementary Details Supplementary Body 1 ncomms10049-s1. initial pathogenic mutation discovered