Leukemia inhibitory element (LIF) has been recently identified as a p53 target gene which mediates the role of p53 in maternal implantation under normal physiological conditions. (e.g. 2-fold difference) impacts greatly upon tumorigenesis 4-6. p53 is under tight regulation by a number of negative regulators including MDM2 MDM4 Wip1 Pirh2 and Cyclin G1 to maintain… Continue reading Leukemia inhibitory element (LIF) has been recently identified as a p53