Autocatalytic phosphorylation of receptor tyrosine kinases (RTKs) enables different context-dependent responses to extracellular signs but comes at the price tag on autonomous ligand-independent activation. the past due endosome/lysosome. We show that this switch from cyclic to unidirectional receptor trafficking converts a continuous suppressive safeguard mechanism into a transient ligand-responsive signalling mode. Eph receptors constitute the… Continue reading Autocatalytic phosphorylation of receptor tyrosine kinases (RTKs) enables different context-dependent responses