In prion diseases synapse dysfunction axon retraction and loss of neuronal polarity precede neuronal death. and dendrite/axon degeneration. This overactivation of ROCK disturbed overall neurotransmitter-associated functions. Importantly we proven that beyond its effect on neuronal polarity Rock and roll overactivity preferred the creation of PrPSc through a ROCK-dependent control of 3-phosphoinositide-dependent kinase 1 (PDK1) activity.… Continue reading In prion diseases synapse dysfunction axon retraction and loss of neuronal