The transcription factor Pit-1 (POU1-F1) plays a dominant role in cell lineage expansion and differentiation in the anterior pituitary. linked to a corresponding shift in higher-order chromatin structures. TC21 This shift establishes an autoregulatory circuit that maintains durable expression of Pit-1 throughout adult life. INTRODUCTION Transcriptional controls and developmental programs within the mammalian genome are… Continue reading The transcription factor Pit-1 (POU1-F1) plays a dominant role in cell