The receptors for platelet-derived growth factor (PDGF) and stem cell factor (SCF) are members of the type III class of PTK receptors which are characterized by five Ig-like domains extracellularly and a split kinase domain name intracellularly. BIBX 1382 fusions point mutations and amplifications-drive subpopulations of certain malignancies such as gastrointestinal stromal tumors chronic myelomonocytic… Continue reading The receptors for platelet-derived growth factor (PDGF) and stem cell factor