Pilocytic astrocytoma (PA) may be the most typical pediatric brain tumor. with a BRAFV600E mutation and homozygous CDKN2A/B deletion, therefore molecularly resembling a WHO quality II-III glioma rather than a PA. To date, there are no reported patient-derived PA cell lines, and consequently no model with endogenous expression of the prototypical KIAA1549:BRAF fusion on a… Continue reading Pilocytic astrocytoma (PA) may be the most typical pediatric brain tumor.