Interleukin-8 (IL-8/CXCL8) is definitely a chemokine that increases endothelial permeability during early stages of angiogenesis. treatment and the time course of complex formation is comparable with that of VEGFR2 phosphorylation. Src kinases are involved GSK221149A (Retosiban) upstream of receptor complex formation and VEGFR2 transactivation during IL-8/CXCL8-induced permeability. An inhibitor of Src kinases blocked IL-8/CXCL8-induced VEGFR2… Continue reading Interleukin-8 (IL-8/CXCL8) is definitely a chemokine that increases endothelial permeability during