The stress-activated protein kinase Gcn2 regulates protein synthesis by phosphorylation of translation initiation factor eIF2α. Gcn2 at low degrees of tRNA binding (Gcd- phenotype) while various other substitutions stop kinase activation (Gcn- phenotype) in some instances without changing tRNA binding by Gcn2 in vitro. Extremely the Gcn- substitutions boost affinity from the HisRS domains for… Continue reading The stress-activated protein kinase Gcn2 regulates protein synthesis by phosphorylation of