Alpha-1 antitrypsin (AAT) deficiency is a common single-gene disorder among Northern Europeans and North Americans. at any time from infancy to adulthood and is thought to be owing to toxicity from the Z-AAT mutant protein that folds poorly and forms insoluble polymers within the hepatocyte which is the primary site for AAT production. Thus gene… Continue reading Alpha-1 antitrypsin (AAT) deficiency is a common single-gene disorder among Northern