Purpose Asparaginase is an essential component of pediatric acute lymphoblastic leukemia (ALL) therapy. with a common regimen. Both patients developed hypersensitivity reactions to PEGylated asparaginase and asparaginase early in treatment and they were challenged with native asparaginase. Serum samples were collected for estimating the pharmacokinetic parameters of each patient during native asparaginase therapy. Results Challenges… Continue reading Purpose Asparaginase is an essential component of pediatric acute lymphoblastic leukemia