A central question in genomic imprinting is how parental-specific DNA methylation of imprinting control regions (ICR) is established during gametogenesis and preserved after fertilization. Using a mouse with mutations in the March4 holding sites, we discovered that sent mutant ICRs obtained incomplete methylation in somatic tissue maternally, but there was small impact on printed phrase… Continue reading A central question in genomic imprinting is how parental-specific DNA methylation