Intravasation the active entry of primary tumor cells into the vasculature remains the least studied step in the metastatic cascade. carcinoma HEp3-hi/diss. Whereas naturally-acquired or experimentally-induced MMP-1 deficiency substantially suppressed HEp3-hi/diss intravasation supplementation of recombinant MMP-1 to MMP-1-silenced primary tumors restored their impaired vascular dissemination. Surprisingly abrogation of MMP-1 production and activity did not affect… Continue reading Intravasation the active entry of primary tumor cells into the vasculature