We investigated the genotype-dependent therapeutic potential of targeting the PI3K/Akt pathway for thyroid cancers. and OCUT1 cells that harbored genetic alterations in the PI3K/Akt pathway but had no effect on SW1736 and KAT18 cells that did not. Transfection with PIK3CA mutants greatly sensitized SW1736 cells to perifosine and temsirolimus. Growth of xenograft tumors derived from… Continue reading We investigated the genotype-dependent therapeutic potential of targeting the PI3K/Akt pathway