The proteasome is an essential cellular machine that maintains protein homeostasis, which is of particular importance in multiple myeloma and perhaps additional cancers. including those resistant to bortezomib. Proteomic evaluation exposed that capzimin stabilized a subset of polyubiquitinated substrates. Recognition of capzimin provides an alternative way to develop proteasome inhibitors for tumor therapy. Intro The… Continue reading The proteasome is an essential cellular machine that maintains protein homeostasis,