cAMP-dependent protein kinase (PKA) regulates the L-type calcium channel the ryanodine receptor and phospholamban (PLB) thereby increasing inotropy. enhanced in cardiomyocytes by chemical p38 inhibition by overexpression of dominating bad p38α and Rabbit Polyclonal to DIL-2. by p38α RNAi but not with dominating bad p38β. Treatment of cardiomyocytes with dominating negative p38α significantly decreased Ca2+-transient… Continue reading cAMP-dependent protein kinase (PKA) regulates the L-type calcium channel the ryanodine