Supplementary Materialsspectra. therapeutic purposes. Currently, a series of natural products and their derivatives, in particular, pladienolide B (1), spliceostatin A (2), and herboxidiene (3) are known to inhibit spliceosome function by binding to the SF3B subunit of U2 snRNP.12,14,15 The precise biochemical interactions of these natural products with these proteins are not clear. Interestingly, the… Continue reading Supplementary Materialsspectra. therapeutic purposes. Currently, a series of natural products and
Tag: Rabbit Polyclonal to MCPH1.
Acrylamide (ACR) is an electrophilic unsaturated carbonyl derivative that produces neurotoxicity
Acrylamide (ACR) is an electrophilic unsaturated carbonyl derivative that produces neurotoxicity by forming irreversible Michael-type adducts with nucleophilic sulfhydryl thiolate organizations about cysteine residues of neuronal proteins. N27 cells were characterized based on the presumed involvement of CNS dopaminergic damage in ACR neurotoxicity. Shotgun proteomics recognized a total of 15 243 peptides in N27 cells… Continue reading Acrylamide (ACR) is an electrophilic unsaturated carbonyl derivative that produces neurotoxicity