BACKGROUND AND PURPOSE The mechanisms by which the dietary compound tangeretin has anticancer effects may include acting as a prodrug, forming an antiproliferative product in cancer cells. Akt/mTOR/p70S6K kinase cascades. The tangeretin metabolite 4-OH-TMF selectively inhibited S6K phosphorylation in the absence of significant inhibition of upstream Akt activity, suggesting an effect at the level of… Continue reading BACKGROUND AND PURPOSE The mechanisms by which the dietary compound tangeretin