Recent advances in long-range Hi-C contact mapping have revealed the importance of the 3D structure of chromosomes in gene expression. model also reveals the existence of several negative drivers that counteract the presence of domain borders including P300, RXRA, ELK1 and BCL11A. Author Summary Chromosomal DNA is tightly packed up in 3D such that around… Continue reading Recent advances in long-range Hi-C contact mapping have revealed the importance