Coordinated serotonin (5-HT) synthesis and reuptake depends on coexpression of Tph2 Aadc and Sert in brain 5-HT neurons. immunoprecipitation and DNA binding assays have demonstrated that Pet-1 coordinates manifestation of these serotonergic genes through direct binding to a common conserved ETS DNA Rabbit Polyclonal to UNG. binding site in their promoter areas (11 12 Although… Continue reading Coordinated serotonin (5-HT) synthesis and reuptake depends on coexpression of Tph2