Background The adult mammalian heart responds to cardiac injury by formation of persistent fibrotic scar that eventually leads to heart failure. Findings These results demonstrate that cryoinjury in neonatal heart prospects to the formation of fibrotic cells that entails Wnt\responsive epicardial cells undergoing epithelial\to\mesenchymal transition to give rise to fibroblasts and account activation of Wnt… Continue reading Background The adult mammalian heart responds to cardiac injury by formation