Ovarian clear-cell carcinoma (OCCC) is an aggressive form of ovarian cancer with high mutation rates. gene expression comparisons support a role for IL-6 inflammatory cytokine signaling in OCCC pathogenesis. We further show that and mutations cooperate to promote tumor growth through sustained IL-6 overproduction. Our findings establish an epistatic relationship between SWI/SNF chromatin remodeling and… Continue reading Ovarian clear-cell carcinoma (OCCC) is an aggressive form of ovarian cancer