Wnt signalling maintains the undifferentiated condition of intestinal crypt/progenitor cells through the TCF4/β-catenin-activating transcriptional complex. expression of TNIK kinase mutants abrogated TCF-LEF transcription highlighting the Rabbit polyclonal to AMPK gamma1. essential function of the kinase activity in Wnt target gene activation. binding and kinase assays show that TC-E 5001 TNIK directly binds both TCF4 and… Continue reading Wnt signalling maintains the undifferentiated condition of intestinal crypt/progenitor cells through