Cytolethal distending toxin (CDT), a genotoxin made by infection and the development of potential clinical applications of CDT. This review provides an overview of recent studies and advancements that address Cj-CDT-cell interactions and intracellular trafficking pathways at the molecular level. Additionally, we discuss several novel strategies for developing CDT into a cancer therapeutic and its… Continue reading Cytolethal distending toxin (CDT), a genotoxin made by infection and the
Tag: Y-33075
Myotonic dystrophy type 1 (DM1) can be an RNA dominant disease
Myotonic dystrophy type 1 (DM1) can be an RNA dominant disease in which mutant transcripts containing an expanded CUG repeat (CUGexp) cause muscle dysfunction by interfering with biogenesis of other mRNAs. mechanisms for dysregulation we performed global mRNA profiling in transgenic mice that express CUGexp RNA when compared with IgG2a/IgG2b antibody (FITC/PE) knockout and null… Continue reading Myotonic dystrophy type 1 (DM1) can be an RNA dominant disease